Sakamakon balaguro na abubuwan tarihi game da cutar ta Alzheimer, an yi ƙoƙari da yawa don amfani da waɗannan alamun nazarin halittu a matsayin alamomi masu nuna alamun ci gaba.MCI[1]. Koyaya, nazarin-meta da yawa ba su bayar da hujjoji bayyananne ba game da rawar da wasu gwaje-gwaje kamar FDG-PET suka yi[4], PET-amyloid[5] da alamomin giya[3] a tsinkaye wanda mutane da ke dauke da MCI za su kamu da waƙar cutar Alzheimer.

Researchungiyar bincike ta Ostiraliya[2] sai ya gwada don gano farkon MCI wanda zai tabbatar da kasancewar ainihin ɓacin rai ta hanyar ƙididdigar ƙwaƙwalwar ƙwaƙwalwa na tushe.

Binciken

Don cimma wannan, Bradfield[2] da abokan aiki sun ƙaddamar da ƙungiyar tsofaffi 725 ga tantance neuropsychological farko sannan kuma ga daya kimantawa bayan shekaru 3, tare da wadannan dalilai:


  • fahimci wane ne ya ci gaba na gaske Alzheimer nau'in ciwon ciki
  • fahimci abin da nake kasawa mai hankali wanda ke kara hadarin wannan dementia (ƙwaƙwalwa, hankali, harshe, ayyukan zartarwa da kuma damar iyar da gani).

Dangane da sakamako na ƙididdigar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, batutuwa da aka tsara a matsayin nau'in amnesic na MCI (aMCI) sun kasu kashi biyu-ƙananan rukuni dangane da sa hannun yanki ɗaya na ilimin fahimi ko yanki daban-daban: MCI tare da raunin ƙwaƙwalwar kawai (Single yanki amnesic MCI) ed Amnesic MCI tare da rikicewar fahimta daban-daban (Multidomain amnesic MCI).
A ƙarshe, dangane da wasan kwaikwayon a gwajin ƙwaƙwalwar ƙwaƙwalwar ajiya, an sake ƙarin yanki ta hanyar matakin daidaitawa: aji na 1 (mai laushi) e aji na 2 (Mai tsananin).
Matsayin yin sulhu da aka yi amfani da shi ya kasance kamar haka: ƙananan aiki ƙasa da 1,5 daidaitattun karkacewa fiye da matsakaici zuwa matsakaici (aji 1) da aikin da yake ƙasa da ƙasa 2,29 daidaitattun karkacewa sama da matsakaici (aji 2).

Sakamakon

Wasu bayanan da aka kirkira sun kasance masu hasara yayin da wasu kila za su iya zama da ban sha'awa:

  • Dukkanin rukuni na Nau'in Amnesic na MCI avevano mafi kusantar su nuna wa ciwon ciki Nau'in Alzheimer bayan shekara 3.
  • Batutuwa da Digiri na biyu digiri na biyu MCI suna da Darajar jujjuyawa zuwa dilaji mafi girma fiye da waɗanda suke aji 1 (milder).
  • da Multidomain amnesic MCIs sun fi yiwuwa na waɗanda a cikin wani yanki daya bayan wani lokaci don bayyana dementias na Alzheimer.
  • Bayan shekaru 3 da 24% na MCI sun sami ci gaba zuwa gajiyawar zuciya (kusan 8% kowace shekara).
  • Abubuwan da suka fi fuskantar hadarin sune wadanda suke da su md-aMCI aji na 2, tare da farashin shekara-shekara na yi hira da 22%.

Lusarshe da abinci don tunani

Yayin kimantawa da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa don tsammanin raunin hankali fannoni da yawa suna buƙatar kimantawa kuma bawai kasancewar / rashin raunin hankali bane.

Yana da mahimmanci cewa kimantawa yayi yawa kuma cewa ba ku fada cikin wannan ba tabbatar da nuna bambanci (misali "Ina zargin cutar taƙasa ta Alzheimer, to kawai nima na nemi ɓarkewar hotunan wannan hoton") amma sauran yanayi kuma ba a cire su ("Idan maganganun na ba daidai bane ba zan iya samun waɗannan alamun bayyanin na asibiti don haka sai na bincika / ban rashi ba").

Extendedididdigar kimantawa tana ba da damar ganowa ko ware abubuwa masu haɗari waɗanda zasu iya ba da shawara cewa hoton asibiti na MCI na iya wakiltar ainihin cutarwar farko. Kamar yadda muka gani daga sakamakon bincike, kasancewar mafi karancin raunin hankali na kara hadarin hakan kuma har ma idan daya daga cikin lahani ya fi girma, kusan sauyi yana nuna yiwuwar ci gaba zuwa ga nau'in cutar ta Alzheimer.

Un m kashi ana bayar da shi ta nau'ikan kwallaye daban-daban wadanda aka saba dasu a yanayin Italiyanci idan aka kwatanta da na duniya: a cikin bincike, ana la'akari da batutuwa tare da MCI aji na 2 (mafi tsanani) idan ƙarfin aikin su a cikin gwajin ƙwaƙwalwar ajiya ya fi 2,29 daidaituwa karkatacciyar ƙasa. A Italiya, kodayake, kusan ba a taɓa amfani da gwaje-gwaje a gwaje-gwajen neuropsychological misali karkacewa. Mafi kyawun aiwatarwa shine daidai maki wanda aka rarraba a cikin jerin ayyukan cika 5 daga 0 zuwa 4: ƙimar 0 tana nuna ƙarancin aiki da ƙasa da kusan kashi 5 na jama'a (galibi ana ayyana ƙarancinsu) kuma ci guda 4 na nuna wasan yayi daidai da ko girma na median. (Kashi 50 cikin dari na yawan jama'a). Sauran sakamakon (1, 2 da 3) basu da madaidaicin matsayin "asibiti".
A takaice dai, alamun da ke fitowa daga binciken kasa da kasa yawanci kan sami cikas ga aikace-aikacen a kasarmu sakamakon banbanci idan aka kwatanta da sauran.

Ban da haka, muna sake maimaita hakan, don samun ingantaccen bayani game da matsayin mai haƙuri da mahimmancin alamu na hoto a kan hotonsa na asibiti, ƙididdigar ƙididdigar ƙwaƙwalwar ƙwaƙwalwa tana da mahimmanci, wato, ba a iyakance ga yanki ɗaya ba ko, mafi muni har yanzu, zuwa gwajin gwaji ( misali MMSE).

Bibliography

  1. Albert, MS, DeKosky, ST, Dickson, D., Dubois, B., Feldman, HH, Fox, NC,… & Snyder, PJ (2011). Binciken asali na rashin lahani na rashin hankali saboda cutar Alzheimer: Shawarwari daga Cibiyar Nazarin Instituteungiyar tsufa-Alzheimer ta onungiyar haɗin gwiwa kan jagororin binciken cutar Alzheimer. Alzheimer & lalata7(3), 270-279.
  2. Bradfield, NI, Ellis, KA, Savage, G., Maruff, P., Burnham, S., Darby, D.,… & Robertson, J. (2018). Elinearancin amnestic ƙarancin jiki yayi hasashen ci gaba daga rashin lahani na rashin hankali ga cutar rashin ƙwaƙwalwar Alzheimer a shekaru 3. Cutar Alzheimer & Rashin Lafiya, 32 (3), 190-196.
  3. Ritchie, C., Smailagic, N., Noel - Storr, AH, Ukoumunne, O., Ladds, EC, & Martin, S. (2017). CSF tau da CSF tau / ABeta rabo ga ganewar asali na Alzheimer ta cutar gigin-tsufa da kuma sauran dementias a mutane da m fahimi hanawa (MCI). Cochrane Database na Binciken Tsare-tsare, (3).
  4. Smailagic, N., Vacante, M., Hyde, C., Martin, S., Ukoumunne, O., & Sachpekidis, C. (2015). 18 F - FDG PET don ganewar asali game da cutar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa. Cochrane Database na Tsare-tsaren Tsaro, (1).
  5. Zhang, S., Smailagic, N., Hyde, C., Noel - Storr, AH, Takwoingi, Y., McShane, R., & Feng, J. (2014). 11 C - PIB - Pet ga farkon ganewar asali na Alzheimer ta cutar gigin-tsufa da kuma sauran dementias a mutane da m fahimi hanawa (MCI). Cochrane Database of Manyan Labarai, (7).

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